ATP activates bestrophin ion channels through direct interaction

Yu Zhang; Alec Kittredge; Nancy Ward; Changyi Ji; Shoudeng Chen; Tingting Yang

doi:10.1038/s41467-018-05616-4

Nature Communications (Aug 2018)

ATP activates bestrophin ion channels through direct interaction

Yu Zhang,
Alec Kittredge,
Nancy Ward,
Changyi Ji,
Shoudeng Chen,
Tingting Yang

Affiliations

Yu Zhang: Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry
Alec Kittredge: Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry
Nancy Ward: Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry
Changyi Ji: Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry
Shoudeng Chen: Molecular Imaging Center, Department of Experimental Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai
Tingting Yang: Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry

DOI: https://doi.org/10.1038/s41467-018-05616-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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