Rational choice of vaginal drug formulation

Abstract

A.S. Dukhanin, O.E. Semioshina Pirogov Russian National Research Medical University, Moscow, Russian Federation This article addresses and supports the criteria for adequate choice of vaginal drug formulation. Comparative pharmaceutical and pharmacological properties of vaginal tablets and vaginal suppositories are reviewed. The effects of the shape and suppository base on vaginal drug formulation choice are discussed. Rational choice of vaginal medications in terms of drug formulation includes: correspondence of drug formulation to treatment goals (transvaginal drug delivery to the blood flow or topical treatment); coordination of pharmaceutical properties of drug formulation base with rapid and complete release of active components; effective combination of antimicrobial agents considering dosing frequency and course duration of the treatment with individual active components of fixed-dose combination; correspondence of drug formulation to the requirements of good adherence to treatment. Case history illustrates that adequate anti-inflammatory therapy before the colposcopy is requ ired. Major indications to broad-spectrum topical combined vaginal medications are addressed. Choice criteria for these medications are specified. Keywords: suppositories, vaginal tablets, adherence to treatment, active ingredients and excipients, complex topical medications, vaginal infections. For citation: Dukhanin A.S., Semioshina O.E. Rational choice of vaginal drug formulation. Russian Journal of Woman and Child Health. 2019;2(4):314–320.