Nature Communications (Nov 2017)
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
- Fátima Valdés-Mora,
- Cathryn M. Gould,
- Yolanda Colino-Sanguino,
- Wenjia Qu,
- Jenny Z. Song,
- Kylie M. Taylor,
- Fabian A. Buske,
- Aaron L. Statham,
- Shalima S. Nair,
- Nicola J. Armstrong,
- James G. Kench,
- Kenneth M. L. Lee,
- Lisa G. Horvath,
- Minru Qiu,
- Alexei Ilinykh,
- Nicole S. Yeo-Teh,
- David Gallego-Ortega,
- Clare Stirzaker,
- Susan J. Clark
Affiliations
- Fátima Valdés-Mora
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Cathryn M. Gould
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Yolanda Colino-Sanguino
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Wenjia Qu
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Jenny Z. Song
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Kylie M. Taylor
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Fabian A. Buske
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Aaron L. Statham
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Shalima S. Nair
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- James G. Kench
- Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital
- Kenneth M. L. Lee
- Sydney Medical School, University of Sydney
- Lisa G. Horvath
- Sydney Medical School, University of Sydney
- Minru Qiu
- Department of Anatomical Pathology, Sydpath, St Vincent’s Hospital
- Alexei Ilinykh
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Nicole S. Yeo-Teh
- Histone Variants Group, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- David Gallego-Ortega
- St. Vincent’s Clinical School, UNSW Sydney
- Clare Stirzaker
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- Susan J. Clark
- Epigenetics Research Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-017-01393-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the activity of specific enhancers of cancer-related genes.
