Communications Biology (Feb 2022)
Precise control of embolic stroke with magnetized red blood cells in mice
- Yuxiao Jin,
- Peijun Shi,
- Yu Wang,
- Jinghang Li,
- Jiachen Zhang,
- Xinxin Zhao,
- Yaping Ge,
- Yanjie Huang,
- Mengzhun Guo,
- Feidi Wang,
- Bo Ci,
- Xian Xiao,
- Xiaofei Gao,
- Jianrong Xu,
- Bobo Dang,
- Botao Ji,
- Woo-ping Ge,
- Jie-Min Jia
Affiliations
- Yuxiao Jin
- College of Life Sciences, Zhejiang University
- Peijun Shi
- Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province
- Yu Wang
- Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Jinghang Li
- School of Engineering, Westlake University and Institute of Advanced Technology, Westlake Institute for Advanced Study
- Jiachen Zhang
- School of Basic Medical Sciences, Wuhan University
- Xinxin Zhao
- Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Yaping Ge
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- Yanjie Huang
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- Mengzhun Guo
- Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Feidi Wang
- Department of Anesthesiology & Center for Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University
- Bo Ci
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Xian Xiao
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- Xiaofei Gao
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- Jianrong Xu
- Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Bobo Dang
- Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Botao Ji
- Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province
- Woo-ping Ge
- Chinese Institute for Brain Research
- Jie-Min Jia
- Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
- DOI
- https://doi.org/10.1038/s42003-022-03082-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
SIMPLE and SIMPLeR are proposed as models for embolism, the latter reversibly manipulating magnetized red blood cells to occlude cerebral vessels. Both methods induce age-dependent micro-hemorrhage transformation, with microglia/macrophage depletion preventing hemorrhage transformation.
