Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Bart C. Jongbloets; Suzanne Lemstra; Roberta Schellino; Mark H. Broekhoven; Jyoti Parkash; Anita J. C. G. M. Hellemons; Tianyi Mao; Paolo Giacobini; Henriette van Praag; Silvia De Marchis; Geert M. J. Ramakers; R. Jeroen Pasterkamp

doi:10.1038/ncomms14666

Nature Communications (Mar 2017)

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Bart C. Jongbloets,
Suzanne Lemstra,
Roberta Schellino,
Mark H. Broekhoven,
Jyoti Parkash,
Anita J. C. G. M. Hellemons,
Tianyi Mao,
Paolo Giacobini,
Henriette van Praag,
Silvia De Marchis,
Geert M. J. Ramakers,
R. Jeroen Pasterkamp

Affiliations

Bart C. Jongbloets: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Suzanne Lemstra: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Roberta Schellino: Dipartimento di Scienze della Vita e Biologia dei Sistemi and Neuroscience Institute Cavalieri Ottolenghi, University of Torino
Mark H. Broekhoven: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Jyoti Parkash: Centre for Animal Sciences, School of Basic and Applied Sciences, Central University Punjab
Anita J. C. G. M. Hellemons: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
Tianyi Mao: Vollum Institute, Oregon Health & Science University
Paolo Giacobini: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
Henriette van Praag: Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health
Silvia De Marchis: Dipartimento di Scienze della Vita e Biologia dei Sistemi and Neuroscience Institute Cavalieri Ottolenghi, University of Torino
Geert M. J. Ramakers: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht
R. Jeroen Pasterkamp: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht

DOI: https://doi.org/10.1038/ncomms14666
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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