Nature Communications (Aug 2018)
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
- Mandeep K. Gill,
- Tania Christova,
- Ying Y. Zhang,
- Alex Gregorieff,
- Liang Zhang,
- Masahiro Narimatsu,
- Siyuan Song,
- Shawn Xiong,
- Amber L. Couzens,
- Jiefei Tong,
- Jonathan R. Krieger,
- Michael F. Moran,
- Alexandre R. Zlotta,
- Theodorus H. van der Kwast,
- Anne-Claude Gingras,
- Frank Sicheri,
- Jeffrey L. Wrana,
- Liliana Attisano
Affiliations
- Mandeep K. Gill
- Department of Biochemistry, University of Toronto
- Tania Christova
- Department of Biochemistry, University of Toronto
- Ying Y. Zhang
- Department of Molecular Genetics, University of Toronto
- Alex Gregorieff
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Liang Zhang
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Masahiro Narimatsu
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Siyuan Song
- Department of Biochemistry, University of Toronto
- Shawn Xiong
- Department of Biochemistry, University of Toronto
- Amber L. Couzens
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Jiefei Tong
- Program in Cell Biology, Hospital for Sick Children
- Jonathan R. Krieger
- SPARC BioCentre, Hospital for Sick Children
- Michael F. Moran
- Department of Molecular Genetics, University of Toronto
- Alexandre R. Zlotta
- Department of Surgery, Division of Urology, University of Toronto, Mount Sinai Hospital and University Health Network
- Theodorus H. van der Kwast
- Department of Pathology, Toronto General Hospital, University Health Network
- Anne-Claude Gingras
- Department of Molecular Genetics, University of Toronto
- Frank Sicheri
- Department of Biochemistry, University of Toronto
- Jeffrey L. Wrana
- Department of Molecular Genetics, University of Toronto
- Liliana Attisano
- Department of Biochemistry, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-018-05939-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional target of YAP/TAZ, thus providing a feed forward loop to promote tumorigenesis.
