Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

Biwei Yang; Meiyi Li; Wenqing Tang; Weixin Liu; Si Zhang; Luonan Chen; Jinglin Xia

doi:10.1038/s41467-018-03024-2

Nature Communications (Feb 2018)

Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

Biwei Yang,
Meiyi Li,
Wenqing Tang,
Weixin Liu,
Si Zhang,
Luonan Chen,
Jinglin Xia

Affiliations

Biwei Yang: Liver Cancer Institute, Zhongshan Hospital, Fudan University
Meiyi Li: Minhang Branch, Zhongshan Hospital, Fudan University/Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University
Wenqing Tang: Liver Cancer Institute, Zhongshan Hospital, Fudan University
Weixin Liu: Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, CAS Center for Excellence in Animal Evolution and Genetics, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Si Zhang: Key Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University
Luonan Chen: Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, CAS Center for Excellence in Animal Evolution and Genetics, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Jinglin Xia: Liver Cancer Institute, Zhongshan Hospital, Fudan University

DOI: https://doi.org/10.1038/s41467-018-03024-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Biomarkers of the tipping point before metastasis in hepatocellular carcinoma (HCC) could help stratify patient treatment. Here, the authors study dynamic network biomarkers to identify CALM3 as a potential suppressor of metastasis, the level of which can predict overall survival and relapse-free survival in postoperative HCC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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