Nature Communications (Feb 2019)

A molecular mechanism for transthyretin amyloidogenesis

  • Ai Woon Yee,
  • Matteo Aldeghi,
  • Matthew P. Blakeley,
  • Andreas Ostermann,
  • Philippe J. Mas,
  • Martine Moulin,
  • Daniele de Sanctis,
  • Matthew W. Bowler,
  • Christoph Mueller-Dieckmann,
  • Edward P. Mitchell,
  • Michael Haertlein,
  • Bert L. de Groot,
  • Elisabetta Boeri Erba,
  • V. Trevor Forsyth

DOI
https://doi.org/10.1038/s41467-019-08609-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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A number of disease-causing human transthyretin (TTR) mutations are known to lead to amyloid formation. Here the authors combine neutron crystallography, native mass spectrometry and modelling studies to characterize the T119M and S52P-TTR mutants, providing mechanistic insights into TTR amyloidosis.