Experience of intestinal automicroflora drugs use in patients with functional disorders in the complex therapy of psoriasis vulgaris

Abstract

The aim was to evaluate the efficacy of intestinal automicroflora medications use in complex therapy in patients with psoriasis vulgaris. The study involved 80 patients with advanced psoriasis vulgaris (mean age 40.5 ± 6.6 years) and 40 dermatologically healthy individuals. The presence and severity of the main intestinal symptoms were determined using the GSRS questionnaire, the quality of life was assessed according to the results of the DLQI dermatological questionnaire, and the severity of psoriasis was determined using the PASI index. The main group of patients with psoriasis vulgaris was divided into two groups depending on the treatment: group I received standard therapy for psoriasis, group II – combined treatment, including standard therapy, correction of microelement status and intestinal automicroflora medications. The results of the study are presented as M ± SD. Statistical data processing, reliability of results at p < 0.05. Results: the average value of the PASI index in patients of the main group was 48.88 ± 9.27 points, according to the DLQI questionnaire – 19.48 ± 6.25 points. According to the GSRS questionnaire, a high prevalence and severity of the main intestinal syndromes in the group of patients with psoriasis vulgaris was established, statistically significant of them – pain, dyspepsia and constipation (p < 0.05). After complex treatment, including standard therapy for the psoriasis vulgaris treatment, correction of the microelement status and oral administration of intestinal automicroflora preparations, there was significant decrease in the prevalence and severity of the main gastroenterological syndromes, a decrease in the PASI index (9.55 ± 4.00 points) and improvement quality of life DLQI (8.40 ± 5.24 points), in comparison with the group of patients receiving standard therapy, where the PASI index after treatment was 47.42 ± 11.22 points, the dermatological index of quality of life DLQI was 15.87 ± 3.84 points. The use of automicroflora preparations is highly effective and can be used in the treatment of not only gastroenterological diseases, but also in the complex therapy of psoriasis vulgaris.

Keywords

• psoriasis vulgaris
• automicroflora
• functional disorders
• gut microbiota