Inhibition of cyclin-dependent kinase 5 (Cdk5) increases osteoblast differentiation and bone mass through the MAPK pathway

• Mubashir Ahmad,
• Torsten Kroll,
• Ann-Kristin Picke,
• Sabine Vettorazzi,
• Florian Mengele,
• Dilay Yilmaz,
• Stolz Miriam,
• Naveen Kumar Tangudu,
• David Carro Vázquez,
• Johanna Pachmayr,
• Maja Vujic Spasic,
• Aspasia Ploubidou,
• Jan Tuckermann

Affiliations

Mubashir Ahmad

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany; Corresponding author.

Torsten Kroll

Leibniz Institute on Aging – Fritz Lipmann Institute, Beutenbergstrasse 11, D-07745, Jena, Germany

Ann-Kristin Picke

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany

Sabine Vettorazzi

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany

Florian Mengele

Department of trauma surgery- hand surgery and orthopaedics- Klinikum Memmingen, Bismarckstrasse 23, 87700, Memmingen, Germany

Dilay Yilmaz

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany

Stolz Miriam

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany

Naveen Kumar Tangudu

UPMC Hillman Cancer Center- University of Pittsburgh, 5115 Center Avenue, 15232, Pittsburgh, United States

David Carro Vázquez

TAmiRNA GmbH, Leberstrasse 20, 1110, Vienna, Austria

Johanna Pachmayr

Institute of Pharmacy- Paracelsus Medizinische Privatuniverstät, Strubergasse 21, 5020, Salzburg, Austria

Maja Vujic Spasic

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany

Aspasia Ploubidou

Leibniz Institute on Aging – Fritz Lipmann Institute, Beutenbergstrasse 11, D-07745, Jena, Germany

Jan Tuckermann

Institute of Comparative Molecular Endocrinology- Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany