BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Yingnan Geng; Huichuan Duan; Liang Xu; Nevin Witman; Bingqian Yan; Zheyuan Yu; Huijing Wang; Yao Tan; Liqin Lin; Dong Li; Shanshan Bai; Regina Fritsche-Danielson; Jie Yuan; Kenneth Chien; Min Wei; Wei Fu

doi:10.1038/s42003-020-01606-9

Communications Biology (Jan 2021)

BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Yingnan Geng,
Huichuan Duan,
Liang Xu,
Nevin Witman,
Bingqian Yan,
Zheyuan Yu,
Huijing Wang,
Yao Tan,
Liqin Lin,
Dong Li,
Shanshan Bai,
Regina Fritsche-Danielson,
Jie Yuan,
Kenneth Chien,
Min Wei,
Wei Fu

Affiliations

Yingnan Geng: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Huichuan Duan: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Liang Xu: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Nevin Witman: Department of Medicine, Karolinska Institutet
Bingqian Yan: Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Zheyuan Yu: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Huijing Wang: Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Yao Tan: Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Liqin Lin: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Dong Li: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Shanshan Bai: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Regina Fritsche-Danielson: Research and Early Clinical Development, Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca
Jie Yuan: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Kenneth Chien: Department of Medicine, Karolinska Institutet
Min Wei: Department of Plastic and Reconstructive Surgery, Shanghai 9th People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Wei Fu: Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s42003-020-01606-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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