Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3

Francesco Ansideri; Joana T. Macedo; Michael Eitel; Ahmed El-Gokha; Dhafer S. Zinad; Camilla Scarpellini; Mark Kudolo; Dieter Schollmeyer; Frank M. Boeckler; Bärbel S. Blaum; Stefan A. Laufer; Pierre Koch

doi:10.1021/acsomega.8b00668

ACS Omega (Jul 2018)

Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c‑Jun N‑Terminal Kinase 3

Francesco Ansideri,
Joana T. Macedo,
Michael Eitel,
Ahmed El-Gokha,
Dhafer S. Zinad,
Camilla Scarpellini,
Mark Kudolo,
Dieter Schollmeyer,
Frank M. Boeckler,
Bärbel S. Blaum,
Stefan A. Laufer,
Pierre Koch

Affiliations

Francesco Ansideri: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Joana T. Macedo: Interfaculty Institute of Biochemistry, Eberhard Karls Universität Tübingen, Tübingen, Germany
Michael Eitel: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Ahmed El-Gokha: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Dhafer S. Zinad: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Camilla Scarpellini: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Mark Kudolo: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Dieter Schollmeyer: Department of Organic Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
Frank M. Boeckler: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Bärbel S. Blaum: Interfaculty Institute of Biochemistry, Eberhard Karls Universität Tübingen, Tübingen, Germany
Stefan A. Laufer: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany
Pierre Koch: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany

DOI: https://doi.org/10.1021/acsomega.8b00668
Journal volume & issue: Vol. 3, no. 7
pp. 7809 – 7831

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Published in ACS Omega

ISSN: 2470-1343 (Online)
Publisher: American Chemical Society
Country of publisher: United States
LCC subjects: Science: Chemistry
Website: https://pubs.acs.org/journal/acsodf

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