State of immune status in hematological patients with invasive aspergillosis

E. V. Frolova; O. V. Shadrivova; L. V. Filippova; A. E. Uchevatkina; A. G. Volkova; M. O. Popova; L. S. Zubarovskaya; I. S. Zjuzgin; T. S. Bogomolova; N. V. Vasilyeva; B. V. Afanasyev; N. N. Klimko

doi:10.22625/2072-6732-2012-4-4-59-64

Журнал инфектологии (Sep 2014)

State of immune status in hematological patients with invasive aspergillosis

E. V. Frolova,
O. V. Shadrivova,
L. V. Filippova,
A. E. Uchevatkina,
A. G. Volkova,
M. O. Popova,
L. S. Zubarovskaya,
I. S. Zjuzgin,
T. S. Bogomolova,
N. V. Vasilyeva,
B. V. Afanasyev,
N. N. Klimko

Affiliations

E. V. Frolova: Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
O. V. Shadrivova: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
L. V. Filippova: Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
A. E. Uchevatkina: Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
A. G. Volkova: Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
M. O. Popova: Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
L. S. Zubarovskaya: Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
I. S. Zjuzgin: Leningrad Regional Clinical Hospital, Saint-Petersburg
T. S. Bogomolova: Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
N. V. Vasilyeva: Science Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg
B. V. Afanasyev: Institute of Children Hematology and Transplantation named after R.M. Gorbacheva of Saint-Petersburg State Medical University named after I.P. Pavlov, Saint-Petersburg
N. N. Klimko: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

DOI: https://doi.org/10.22625/2072-6732-2012-4-4-59-64
Journal volume & issue: Vol. 4, no. 4
pp. 59 – 64

Abstract

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Invasive aspergillosis – is severe mycotic infection that often occurs in hematological patients and is characterized by high mortality. We examined the immunological parameters of hematological patients with invasive aspergillosis developed after cytostatic chemotherapy. Was founded, disruption of all parts of the immune respons: reduction in the absolute number of T-helper cells (CD4 +), natural killer cells (CD16 +), lowering of IFN-γ and IL-10 production, reduction in the number of B-lymphocytes and immunoglobulin levels of all classes, suppression killer ability of neutrophils are features of immune status in hematological patients with invasive aspergillosis receiving cytostatic chemotherapy.

Published in Журнал инфектологии

ISSN: 2072-6732 (Print)
Publisher: Journal Infectology
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: http://journal.niidi.ru/

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