Combustion synthesis of sponge-like CeO2 powder for selective determination of uric acid in biological fluids

Abstract

Sponge-like porous cerium oxide particles were prepared through the self-propagating high-temperature synthesis process. Then, the synthesized powder was used to modify the carbon paste electrode (CPE/porous CeO2) for voltammetric determination of uric acid (UA) in biological fluids. Under optimal conditions, the linear concentration-response relationship was in the range of 0.25-10 and 10-300 µM, and a detection limit of 60 nM (S/N=3) was obtained. In addition, the proposed sensor showed excellent selectivity towards UA over common co-existing species such as ascorbic acid, ibuprofen, dopamine, and acetaminophen. Good repeatability of sensor responses (Relative standard deviation (RSD) < 3.2%), superior reproducibility (RSD < 2.8%), and excellent storage stability (error < 5% after 1 month storage at room temperature) along with appropriate recovery values (in the range of 99.2 -102.7%) demonstrate the applicability of CPE/porous CeO2 for the determination of UA levels in biological fluids.

Keywords

• porous cerium oxide powder
• modified carbon paste electrode
• uric acid
• voltammetric determination