Long-Term Effects of Kasai Portoenterostomy for Biliary Atresia Treatment in Russia
Anna Degtyareva,
Alexander Razumovskiy,
Nadezhda Kulikova,
Sergey Ratnikov,
Elena Filippova,
Ekaterina Gordeeva,
Marina Albegova,
Denis Rebrikov,
Anna Puchkova
Affiliations
Anna Degtyareva
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparina Street, 117997 Moscow, Russia
Alexander Razumovskiy
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova Street, 117997 Moscow, Russia
Nadezhda Kulikova
Filatov Munitsipal Children’s Hospital, 15 Sadovaya-Kudrinskaya Street, 123001 Moscow, Russia
Sergey Ratnikov
National Medical Research Center for Children’s Health, 2 Lomonosovsky Prospect, 119296 Moscow, Russia
Elena Filippova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparina Street, 117997 Moscow, Russia
Ekaterina Gordeeva
Filatov Munitsipal Children’s Hospital, 15 Sadovaya-Kudrinskaya Street, 123001 Moscow, Russia
Marina Albegova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparina Street, 117997 Moscow, Russia
Denis Rebrikov
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparina Street, 117997 Moscow, Russia
Anna Puchkova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 Oparina Street, 117997 Moscow, Russia
This prospective study enrolled 144 patients after surgical treatment of biliary atresia in early infancy. We analyzed the immediate effectiveness of the surgery and the age-related structure of complications in the up to 16-year follow-up. The immediate 2-year survival rate after the surgery constituted 49.5%. At the time of this writing, 17 of the patients had celebrated their 10th birthdays with good quality of life and no indications for transplantation of the liver. The obtained results underscore the critical importance of surgical correction of biliary atresia by Kasai surgery in the first 60 days of life and subsequent dynamic follow-up of patients for the purpose of the early detection and timely correction of possible complications.
