Nature Communications (Sep 2019)
Tumor-reprogrammed resident T cells resist radiation to control tumors
- Ainhoa Arina,
- Michael Beckett,
- Christian Fernandez,
- Wenxin Zheng,
- Sean Pitroda,
- Steven J. Chmura,
- Jason J. Luke,
- Martin Forde,
- Yuzhu Hou,
- Byron Burnette,
- Helena Mauceri,
- Israel Lowy,
- Tasha Sims,
- Nikolai Khodarev,
- Yang-Xin Fu,
- Ralph R. Weichselbaum
Affiliations
- Ainhoa Arina
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Michael Beckett
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Christian Fernandez
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Wenxin Zheng
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Sean Pitroda
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Steven J. Chmura
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Jason J. Luke
- Department of Medicine, The University of Chicago
- Martin Forde
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Yuzhu Hou
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Byron Burnette
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Helena Mauceri
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Israel Lowy
- Regeneron Pharmaceuticals
- Tasha Sims
- Regeneron Pharmaceuticals
- Nikolai Khodarev
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- Yang-Xin Fu
- Department of Pathology, University of Texas Southwestern
- Ralph R. Weichselbaum
- Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
- DOI
- https://doi.org/10.1038/s41467-019-11906-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.
