Cellular reprogramming as a tool to model human aging in a dish

Patricia R. Pitrez; Luis M. Monteiro; Oliver Borgogno; Xavier Nissan; Jerome Mertens; Lino Ferreira

doi:10.1038/s41467-024-46004-5

Nature Communications (Feb 2024)

Cellular reprogramming as a tool to model human aging in a dish

Patricia R. Pitrez,
Luis M. Monteiro,
Oliver Borgogno,
Xavier Nissan,
Jerome Mertens,
Lino Ferreira

Affiliations

Patricia R. Pitrez: Center for Neuroscience and Cell Biology, University of Coimbra
Luis M. Monteiro: Center for Neuroscience and Cell Biology, University of Coimbra
Oliver Borgogno: Department of Neurosciences, University of California San Diego
Xavier Nissan: CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic diseases
Jerome Mertens: Department of Neurosciences, University of California San Diego
Lino Ferreira: Center for Neuroscience and Cell Biology, University of Coimbra

DOI: https://doi.org/10.1038/s41467-024-46004-5
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 11

Abstract

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Abstract The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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