Oilseeds and fats, crops and lipids (Jan 2016)

AceDoPC, a structured phospholipid to target the brain with docosahexaenoic acid

  • Lagarde Michel,
  • Hachem Mayssa,
  • Picq Madeleine,
  • Guichardant Michel,
  • Bernoud-Hubac Nathalie

DOI
https://doi.org/10.1051/ocl/2015061
Journal volume & issue
Vol. 23, no. 1
p. D102

Abstract

Read online

AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA made to prevent docosahexaenoic acyl migrating from the sn-2 to sn-1 position of the phospholipid, however keeping the main physical-chemical properties of LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® allows DHA crossing a re-constituted blood-brain barrier with higher efficiency than non-esterified DHA or PC-DHA. When injected to blood of rats, AceDoPC® is processed within the brain to deliver DHA to phosphatidyl-choline and -ethanolamine. When injected to rats following the induction of an ischemic stroke, AceDoPC® prevents the extension of brain lesions more efficiently than DHA. Overall, these properties make AceDoPC® a promising phospholipid carrier of DHA to the brain.

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