Nature Communications (Jan 2023)
Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa
- Elsa du Bruyn,
- Cari Stek,
- Remi Daroowala,
- Qonita Said-Hartley,
- Marvin Hsiao,
- Georgia Schafer,
- Rene T. Goliath,
- Fatima Abrahams,
- Amanda Jackson,
- Sean Wasserman,
- Brian W. Allwood,
- Angharad G. Davis,
- Rachel P.-J. Lai,
- Anna K. Coussens,
- Katalin A. Wilkinson,
- Jantina de Vries,
- Nicki Tiffin,
- Maddalena Cerrone,
- Ntobeko A. B. Ntusi,
- HIATUS consortium,
- Catherine Riou,
- Robert J. Wilkinson
Affiliations
- Elsa du Bruyn
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Cari Stek
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Remi Daroowala
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Qonita Said-Hartley
- Department of Radiology, University of Cape Town
- Marvin Hsiao
- Department of Pathology, University of Cape Town
- Georgia Schafer
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Rene T. Goliath
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Fatima Abrahams
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Amanda Jackson
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Sean Wasserman
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Brian W. Allwood
- Division of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Hospital
- Angharad G. Davis
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Rachel P.-J. Lai
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Anna K. Coussens
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Katalin A. Wilkinson
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Jantina de Vries
- Department of Medicine, University of Cape Town
- Nicki Tiffin
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Maddalena Cerrone
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Ntobeko A. B. Ntusi
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- HIATUS consortium
- Catherine Riou
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Robert J. Wilkinson
- Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- DOI
- https://doi.org/10.1038/s41467-022-35689-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Here the authors describe outcomes of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence. They find that tuberculosis is a common co-morbidity in patients admitted to hospital with COVID-19 and that the immune response to SARS-CoV-2 is adversely affected by co-existent HIV-1 and tuberculosis.
