Nature Communications (Nov 2020)
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers
- Sunil Kumar Saini,
- Andreas Due Ørskov,
- Anne-Mette Bjerregaard,
- Ashwin Unnikrishnan,
- Staffan Holmberg-Thydén,
- Annie Borch,
- Kathrine Valentini Jensen,
- Govardhan Anande,
- Amalie Kai Bentzen,
- Andrea Marion Marquard,
- Tripti Tamhane,
- Marianne Bach Treppendahl,
- Anne Ortved Gang,
- Inge Høgh Dufva,
- Zoltan Szallasi,
- Nicola Ternette,
- Anders Gorm Pedersen,
- Aron Charles Eklund,
- John Pimanda,
- Kirsten Grønbæk,
- Sine Reker Hadrup
Affiliations
- Sunil Kumar Saini
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Andreas Due Ørskov
- Department of Haematology, Rigshospitalet, Copenhagen University Hospital
- Anne-Mette Bjerregaard
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Ashwin Unnikrishnan
- Adult Cancer Program, Lowy Cancer Research Centre, UNSW
- Staffan Holmberg-Thydén
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Annie Borch
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Kathrine Valentini Jensen
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Govardhan Anande
- Adult Cancer Program, Lowy Cancer Research Centre, UNSW
- Amalie Kai Bentzen
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Andrea Marion Marquard
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Tripti Tamhane
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- Marianne Bach Treppendahl
- Department of Haematology, Rigshospitalet, Copenhagen University Hospital
- Anne Ortved Gang
- Department of Haematology, Herlev Hospital, Copenhagen University Hospital
- Inge Høgh Dufva
- Department of Haematology, Herlev Hospital, Copenhagen University Hospital
- Zoltan Szallasi
- Department of Health Technology, Section of Bioinformatics, Technical University of Denmark
- Nicola Ternette
- Nuffield Department of Medicine, University of Oxford
- Anders Gorm Pedersen
- Department of Health Technology, Section of Bioinformatics, Technical University of Denmark
- Aron Charles Eklund
- Department of Health Technology, Section of Bioinformatics, Technical University of Denmark
- John Pimanda
- Adult Cancer Program, Lowy Cancer Research Centre, UNSW
- Kirsten Grønbæk
- Department of Haematology, Rigshospitalet, Copenhagen University Hospital
- Sine Reker Hadrup
- Department of Health Technology, Section of Experimental and Translational Immunology, Technical University of Denmark
- DOI
- https://doi.org/10.1038/s41467-020-19464-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.
