Conformational changes in intact dengue virus reveal serotype-specific expansion

Xin-Xiang Lim; Arun Chandramohan; Xin Ying Elisa Lim; Nirmalya Bag; Kamal Kant Sharma; Melissa Wirawan; Thorsten Wohland; Shee-Mei Lok; Ganesh S. Anand

doi:10.1038/ncomms14339

Nature Communications (Feb 2017)

Conformational changes in intact dengue virus reveal serotype-specific expansion

Xin-Xiang Lim,
Arun Chandramohan,
Xin Ying Elisa Lim,
Nirmalya Bag,
Kamal Kant Sharma,
Melissa Wirawan,
Thorsten Wohland,
Shee-Mei Lok,
Ganesh S. Anand

Affiliations

Xin-Xiang Lim: Department of Biological Sciences, National University of Singapore
Arun Chandramohan: Department of Biological Sciences, National University of Singapore
Xin Ying Elisa Lim: Duke-National University of Singapore Graduate Medical School
Nirmalya Bag: Department of Biological Sciences, National University of Singapore
Kamal Kant Sharma: Department of Biological Sciences, National University of Singapore
Melissa Wirawan: Duke-National University of Singapore Graduate Medical School
Thorsten Wohland: Department of Biological Sciences, National University of Singapore
Shee-Mei Lok: Department of Biological Sciences, National University of Singapore
Ganesh S. Anand: Department of Biological Sciences, National University of Singapore

DOI: https://doi.org/10.1038/ncomms14339
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Temperature differences between mosquitoes and humans trigger structural changes in dengue virus 2 (DENV2) particles, but not in other DENV serotypes. Here, using HDXMS, the authors describe serotype-specific expansion of intact viral particles of DENV1 and DENV2 at 28 °C (mosquitoes), 37 °C (humans) and 40 °C (fever).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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