Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Oya Cingöz; John M. Coffin

doi:10.1155/2011/940210

Advances in Virology (Jan 2011)

Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Oya Cingöz,
John M. Coffin

Affiliations

Oya Cingöz: Department of Molecular Biology and Microbiology and Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
John M. Coffin: Department of Molecular Biology and Microbiology and Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA

DOI: https://doi.org/10.1155/2011/940210
Journal volume & issue: Vol. 2011

Abstract

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Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples.

Published in Advances in Virology

ISSN: 1687-8639 (Print); 1687-8647 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Microbiology
Website: https://onlinelibrary.wiley.com/journal/9171

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