Spectroscopic and thermal degradation behavior of Mg(II), Ca(II), Ba(II) and Sr(II) complexes with paracetamol drug

Abstract

Complexes of Mg(II), Ca(II), Ba(II) and Sr(II) with paracetamol drug were synthesized and characterized by elemental analysis, conductivity, UV–Vis, IR, and 1H NMR spectroscopy and thermal analysis, as well as screened for antimicrobial activity. The IR spectral data suggested that the ligand behaves as paracetamol behaves as a neutral bidentate ligand coordinated to the metal ions via the lone pair of electrons of nitrogen and carbonyl-O atoms of the amide group. From the microanalytical data, the stoichiometry of the complexes reacts with Mg(II), Ca(II), Ba(II) and Sr(II) by molar ratios (2:1) (paracetamol:metal ion). The thermal behavior (TG/DTG) of the complexes was studied. The ligand and their metal complexes were screened against both of antibacterial and fungicidal activities.

Keywords

• Paracetamol
• Divalent state metal complexes
• Thermal analysis
• Antimicrobial activity