Biomedicines (Nov 2023)

Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects

  • Elena Garcia-Martin,
  • Daniel Jimeno-Huete,
  • Francisco J. Dongil-Moreno,
  • Luciano Boquete,
  • Eva M. Sánchez-Morla,
  • Juan M. Miguel-Jiménez,
  • Almudena López-Dorado,
  • Elisa Vilades,
  • Maria I. Fuertes,
  • Ana Pueyo,
  • Miguel Ortiz del Castillo

DOI
https://doi.org/10.3390/biomedicines11123126
Journal volume & issue
Vol. 11, no. 12
p. 3126

Abstract

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Multiple sclerosis (MS) and Alzheimer’s disease (AD) cause retinal thinning that is detectable in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases in terms of the structural differences they produce in the retina. The purpose of this study is to analyse and compare the neuroretinal structure in MS patients, AD patients and healthy subjects using OCT. Spectral domain OCT was performed on 21 AD patients, 33 MS patients and 19 control subjects using the Posterior Pole protocol. The area under the receiver operating characteristic (AUROC) curve was used to analyse the differences between the cohorts in nine regions of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL). The main differences between MS and AD are found in the ONL, in practically all the regions analysed (AUROCFOVEAL = 0.80, AUROCPARAFOVEAL = 0.85, AUROCPERIFOVEAL = 0.80, AUROC_PMB = 0.77, AUROCPARAMACULAR = 0.85, AUROCINFERO_NASAL = 0.75, AUROCINFERO_TEMPORAL = 0.83), and in the paramacular zone (AUROCPARAMACULAR = 0.75) and infero-temporal quadrant (AUROCINFERO_TEMPORAL = 0.80) of the GCL. In conclusion, our findings suggest that OCT data analysis could facilitate the differential diagnosis of MS and AD.

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