CD200Fc Improves Neurological Function by Protecting the Blood–brain Barrier after Intracerebral Hemorrhage

Chen-sheng Le; Xiao-di Hao; Jia-wen Li; Jia-wei Zhong; Hao-ran Lin; Yi-ting Zhou; Zachary D. Travis; Lu-sha Tong; Feng Gao

doi:10.1177/0963689719857655

Cell Transplantation (Sep 2019)

CD200Fc Improves Neurological Function by Protecting the Blood–brain Barrier after Intracerebral Hemorrhage

Chen-sheng Le,
Xiao-di Hao,
Jia-wen Li,
Jia-wei Zhong,
Hao-ran Lin,
Yi-ting Zhou,
Zachary D. Travis,
Lu-sha Tong,
Feng Gao

Affiliations

Chen-sheng Le: All the authors contributed equally to this article.
Xiao-di Hao: All the authors contributed equally to this article.
Jia-wen Li: Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Jia-wei Zhong: Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Hao-ran Lin: College of Pharmaceutical Science, Zhejiang University, Hangzhou, Zhejiang, China
Yi-ting Zhou: Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Zachary D. Travis: Loma Linda University, School of Medicine, Earth and Biological Sciences, Loma Linda, CA, USA
Lu-sha Tong: All the authors contributed equally to this article.
Feng Gao: All the authors contributed equally to this article.

DOI: https://doi.org/10.1177/0963689719857655
Journal volume & issue: Vol. 28

Abstract

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CD200 is widely distributed in the central nervous system and plays an essential role in the immune response in neurological diseases. However, little is currently known about the effects of CD200 signaling on the blood–brain barrier (BBB) function after intracerebral hemorrhage (ICH). In this study, the role of CD200 during ICH in an autologous blood induced mouse ICH model was investigated. Following ICH, critical protein expression, BBB permeability, and neurological function were measured with or without CD200Fc administration. Our results showed that both the expression of CD200 and CD200R1 decreased after ICH and administration of CD200Fc attenuated BBB leakage and improved neurological functions. In conclusion, our work demonstrated that CD200Fc might be a potential treatment option for ICH by protecting the BBB and improving functional outcomes.

Published in Cell Transplantation

ISSN: 0963-6897 (Print); 1555-3892 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine
Website: http://journals.sagepub.com/home/cll

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