Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment

M. S. Sobolev; A. V. Faitelson; O. S. Gudyrev; D. S. R. Rajkumar; G. M. Dubrovin; A. V. Anikanov; N. U. Koklina; E. S. Chernomortseva

doi:10.1155/2018/1585749

Journal of Osteoporosis (Jan 2018)

Study of Endothelio- and Osteoprotective Effects of Combination of Rosuvastatin with L-Norvaline in Experiment

M. S. Sobolev,
A. V. Faitelson,
O. S. Gudyrev,
D. S. R. Rajkumar,
G. M. Dubrovin,
A. V. Anikanov,
N. U. Koklina,
E. S. Chernomortseva

Affiliations

M. S. Sobolev: Kursk Regional Children’s Hospital No-2, No-43a, Khutorskaya Street, Kursk, Russia
A. V. Faitelson: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia
O. S. Gudyrev: Department of Pharmacology, Belgorod State National Research University, 85 Pobedy Street, Belgorod, 308015, Russia
D. S. R. Rajkumar: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia
G. M. Dubrovin: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia
A. V. Anikanov: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia
N. U. Koklina: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia
E. S. Chernomortseva: Department of Traumatology and Orthopedics, Kursk State Medical University, No-3 Karl Marx Street, Kursk 305000, Russia

DOI: https://doi.org/10.1155/2018/1585749
Journal volume & issue: Vol. 2018

Abstract

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The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them.

Published in Journal of Osteoporosis

ISSN: 2090-8059 (Print); 2042-0064 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://onlinelibrary.wiley.com/journal/1384

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