Nature Communications (Aug 2018)
The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
- Mette Ø. Agerbæk,
- Sara R. Bang-Christensen,
- Ming-Hsin Yang,
- Thomas M. Clausen,
- Marina A. Pereira,
- Shreya Sharma,
- Sisse B. Ditlev,
- Morten A. Nielsen,
- Swati Choudhary,
- Tobias Gustavsson,
- Poul H. Sorensen,
- Tim Meyer,
- David Propper,
- Jonathan Shamash,
- Thor G. Theander,
- Alexandra Aicher,
- Mads Daugaard,
- Christopher Heeschen,
- Ali Salanti
Affiliations
- Mette Ø. Agerbæk
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Sara R. Bang-Christensen
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Ming-Hsin Yang
- Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London
- Thomas M. Clausen
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Marina A. Pereira
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Shreya Sharma
- Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London
- Sisse B. Ditlev
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Morten A. Nielsen
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Swati Choudhary
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Tobias Gustavsson
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Poul H. Sorensen
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Tim Meyer
- UCL Cancer Institute, University College London
- David Propper
- Department of Medical Oncology, Barts Health NHS
- Jonathan Shamash
- Department of Medical Oncology, Barts Health NHS
- Thor G. Theander
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- Alexandra Aicher
- Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London
- Mads Daugaard
- Vancouver Prostate Centre
- Christopher Heeschen
- Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London
- Ali Salanti
- Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital
- DOI
- https://doi.org/10.1038/s41467-018-05793-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all cancer cells
