Emerging Infectious Diseases (Jan 2012)

Candida spp. with Acquired Echinocandin Resistance, France, 2004–2010

  • Eric Dannaoui,
  • Marie Desnos-Ollivier,
  • Dea Garcia-Hermoso,
  • Fredéric Grenouillet,
  • Sophie Cassaing,
  • Marie-Thérèse Baixench,
  • Stéphane Bretagne,
  • Françoise Dromer,
  • Olivier Lortholary

DOI
https://doi.org/10.3201/eid1801.110556
Journal volume & issue
Vol. 18, no. 1
pp. 86 – 90

Abstract

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We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.

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