Viscoelastic modulus of agarose gels by magnetic resonance elastography using Micro-MRI

Abstract

This study aimed to apply magnetic resonance elastography (MRE) using micro-magnetic resonance imaging (micro-MRI) system for the measurements of viscoelastic modulus in soft matters. The rectangular specimens of 90 × 70 × 50 mm were made of agarose gel with five kinds of stiffness by changing concentrations. The specimens were oscillated with longitudinal waves transmitted by an elastic-bar from a vibration generator in a micro-MRI system. Since the viscoelastic properties depend on the excitation frequency and amplitude, the experimental conditions were selected in the range of 50-250 Hz and 0.1-0.5 mm. The viscoelastic modulus was expressed as storage shear modulus G´ and loss shear modulus G˝. As a result, G´ increased with the frequency and amplitude, and the difference of G´ between hard and soft gels was obtained. The viscoelastic modulus of agarose gels was measured using the MRE system under the excitation conditions. Furthermore, double-layer specimens composed of 0.6 and 2.0 wt% gels were examined as an application of the MRE system. The difference of wave pattern between the hard and soft parts was observed. The values of G´ in the soft parts of the double-layer specimens corresponded to the value of the single-layer specimen, but the values of G´ in the hard parts were varied.

Keywords

• magnetic resonance elastography
• magnetic resonance imaging
• viscoelasticity
• soft matter stiffness
• elastic modulus