Life (Mar 2021)

Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells

  • Elisa Mazuir,
  • Desdemona Fricker,
  • Nathalie Sol-Foulon

DOI
https://doi.org/10.3390/life11030216
Journal volume & issue
Vol. 11, no. 3
p. 216

Abstract

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Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing. The extent and profile of myelination vary between different cortical layers and groups of neurons. Two subtypes of cortical GABAergic neurons are myelinated: fast-spiking parvalbumin-expressing cells and somatostatin-containing cells. The expression of pre-nodes on the axon of these inhibitory cells before myelination illuminates communication between oligodendrocytes and neurons. We explore the consequences of myelination for action potential propagation, for patterns of neuronal connectivity and for the expression of behavioral plasticity.

Keywords