PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow

Abstract

Programmed death ligand 1 (PD-L1) suppresses host immunity during infection and microbial sepsis. Here, the authors show that PD-L1 does this by regulating the secretion of CXCL1 and CXCL2 to control neutrophil mobilization during Candida albicans infection.