Target-responsive vasoactive probes for ultrasensitive molecular imaging

Robert Ohlendorf; Agata Wiśniowska; Mitul Desai; Ali Barandov; Adrian L. Slusarczyk; Nan Li; Alan Jasanoff

doi:10.1038/s41467-020-16118-7

Nature Communications (May 2020)

Target-responsive vasoactive probes for ultrasensitive molecular imaging

Robert Ohlendorf,
Agata Wiśniowska,
Mitul Desai,
Ali Barandov,
Adrian L. Slusarczyk,
Nan Li,
Alan Jasanoff

Affiliations

Robert Ohlendorf: Department of Biological Engineering, Massachusetts Institute of Technology
Agata Wiśniowska: Harvard-MIT Health Sciences & Technology, Massachusetts Institute of Technology
Mitul Desai: Department of Biological Engineering, Massachusetts Institute of Technology
Ali Barandov: Department of Biological Engineering, Massachusetts Institute of Technology
Adrian L. Slusarczyk: Department of Biological Engineering, Massachusetts Institute of Technology
Nan Li: Department of Biological Engineering, Massachusetts Institute of Technology
Alan Jasanoff: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-020-16118-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Noninvasive detection of molecular targets in living subjects could provide valuable insights into healthy function and disease. Here, the authors develop vasoactive imaging probes which allow wide-field in vivo mapping of nanomolar-level molecular species in rat brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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