Effect of serial in vivo passages on the adaptation of H1N1 avian influenza virus to pigs

Abstract

The lack of proofreading activity of the viral polymerase and the segmented nature of the influenza A virus (IAV) genome are responsible for the genetic diversity of IAVs and for their ability to adapt to a new host. We tried to adapt avian IAV (avIAV) to the pig by serial passages in vivo and assessed the occurrence of point mutations and their influence on viral fitness in the pig’s body.

Keywords

• avian influenza virus
• pig
• in vivo adaptation
• mutation
• viral fitness