Nature Communications (Nov 2022)
GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome
- Silvia Tiberti,
- Carlotta Catozzi,
- Ottavio Croci,
- Mattia Ballerini,
- Danilo Cagnina,
- Chiara Soriani,
- Caterina Scirgolea,
- Zheng Gong,
- Jiatai He,
- Angeli D. Macandog,
- Amir Nabinejad,
- Carina B. Nava Lauson,
- Arianna Quinte’,
- Giovanni Bertalot,
- Wanda L. Petz,
- Simona P. Ravenda,
- Valerio Licursi,
- Paola Paci,
- Marco Rasponi,
- Luca Rotta,
- Nicola Fazio,
- Guangwen Ren,
- Uberto Fumagalli-Romario,
- Martin H. Schaefer,
- Stefano Campaner,
- Enrico Lugli,
- Luigi Nezi,
- Teresa Manzo
Affiliations
- Silvia Tiberti
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Carlotta Catozzi
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Ottavio Croci
- Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT)
- Mattia Ballerini
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Danilo Cagnina
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Chiara Soriani
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Caterina Scirgolea
- Laboratory of Translational Immunology, IRCCS- Humanitas Research Hospital-
- Zheng Gong
- The Jackson Laboratory
- Jiatai He
- The Jackson Laboratory
- Angeli D. Macandog
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Amir Nabinejad
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Carina B. Nava Lauson
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Arianna Quinte’
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Giovanni Bertalot
- Department of Pathology, APSS Trento Hospital & Health Care
- Wanda L. Petz
- Digestive Surgery Division, European Institute of Oncology-IRCCS
- Simona P. Ravenda
- Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology-IRCCS
- Valerio Licursi
- Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy
- Paola Paci
- Department of Computer, Control and Management Engineering, Sapienza - University of Rome
- Marco Rasponi
- Department of Electronics, Information and Bioengineering, Politecnico di Milano
- Luca Rotta
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Nicola Fazio
- Digestive Surgery Division, European Institute of Oncology-IRCCS
- Guangwen Ren
- The Jackson Laboratory
- Uberto Fumagalli-Romario
- Digestive Surgery Division, European Institute of Oncology-IRCCS
- Martin H. Schaefer
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Stefano Campaner
- Center for Genomic Science of IIT, CGS@SEMM (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT)
- Enrico Lugli
- Laboratory of Translational Immunology, IRCCS- Humanitas Research Hospital-
- Luigi Nezi
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- Teresa Manzo
- Department of Experimental Oncology, European Institute of Oncology- IRCCS
- DOI
- https://doi.org/10.1038/s41467-022-34467-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce GZMK, associated with tumor progression in CRC patients.
