Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

Jun Wang; David V. Conti; Marta Epeldegui; Miina Ollikainen; Rachel F. Tyndale; Amie Eunah Hwang; Larry Magpantay; Thomas McCulloch Mack; Otoniel Martinez-Maza; Jaakko Kaprio; Wendy Cozen

doi:10.3390/cancers13215395

Cancers (Oct 2021)

Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

Jun Wang,
David V. Conti,
Marta Epeldegui,
Miina Ollikainen,
Rachel F. Tyndale,
Amie Eunah Hwang,
Larry Magpantay,
Thomas McCulloch Mack,
Otoniel Martinez-Maza,
Jaakko Kaprio,
Wendy Cozen

Affiliations

Jun Wang: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
David V. Conti: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Marta Epeldegui: Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Miina Ollikainen: Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
Rachel F. Tyndale: Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, and Campbell Family Mental Health Research Institute, Toronto, ON M5S 1A8, Canada
Amie Eunah Hwang: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Larry Magpantay: Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Thomas McCulloch Mack: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Otoniel Martinez-Maza: Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Jaakko Kaprio: Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
Wendy Cozen: Department of Medicine, Division of Hematology-Oncology, School of Medicine, University of California Irvine, Orange, CA 92868, USA

DOI: https://doi.org/10.3390/cancers13215395
Journal volume & issue: Vol. 13, no. 21
p. 5395

Abstract

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Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p Ptrend Ptrend = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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