Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing

Peter G. Farlie; Nadia M. Davidson; Naomi L. Baker; Mai Raabus; Kelly N. Roeszler; Claire Hirst; Andrew Major; Mylene M. Mariette; David M. Lambert; Alicia Oshlack; Craig A. Smith

doi:10.1038/s41467-017-00112-7

Nature Communications (Jul 2017)

Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing

Peter G. Farlie,
Nadia M. Davidson,
Naomi L. Baker,
Mai Raabus,
Kelly N. Roeszler,
Claire Hirst,
Andrew Major,
Mylene M. Mariette,
David M. Lambert,
Alicia Oshlack,
Craig A. Smith

Affiliations

Peter G. Farlie: Murdoch Children’s Research Institute, Royal Children’s Hospital
Nadia M. Davidson: Murdoch Children’s Research Institute, Royal Children’s Hospital
Naomi L. Baker: Murdoch Children’s Research Institute, Royal Children’s Hospital
Mai Raabus: Murdoch Children’s Research Institute, Royal Children’s Hospital
Kelly N. Roeszler: Murdoch Children’s Research Institute, Royal Children’s Hospital
Claire Hirst: Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University
Andrew Major: Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University
Mylene M. Mariette: Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University
David M. Lambert: Environmental Futures Research Institute, Griffith University
Alicia Oshlack: Murdoch Children’s Research Institute, Royal Children’s Hospital
Craig A. Smith: Murdoch Children’s Research Institute, Royal Children’s Hospital

DOI: https://doi.org/10.1038/s41467-017-00112-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

The transcription factor Nkx2.5 is essential for heart development. Here, the authors identify a previously unknown expression domain for Nkx2.5 in the emu wing and explore its role in diminished wing bud development in the flightless emu, compared with three other birds that have functional wings.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal