Nature Communications (Oct 2019)
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
- Caroline M. Nievergelt,
- Adam X. Maihofer,
- Torsten Klengel,
- Elizabeth G. Atkinson,
- Chia-Yen Chen,
- Karmel W. Choi,
- Jonathan R. I. Coleman,
- Shareefa Dalvie,
- Laramie E. Duncan,
- Joel Gelernter,
- Daniel F. Levey,
- Mark W. Logue,
- Renato Polimanti,
- Allison C. Provost,
- Andrew Ratanatharathorn,
- Murray B. Stein,
- Katy Torres,
- Allison E. Aiello,
- Lynn M. Almli,
- Ananda B. Amstadter,
- Søren B. Andersen,
- Ole A. Andreassen,
- Paul A. Arbisi,
- Allison E. Ashley-Koch,
- S. Bryn Austin,
- Esmina Avdibegovic,
- Dragan Babić,
- Marie Bækvad-Hansen,
- Dewleen G. Baker,
- Jean C. Beckham,
- Laura J. Bierut,
- Jonathan I. Bisson,
- Marco P. Boks,
- Elizabeth A. Bolger,
- Anders D. Børglum,
- Bekh Bradley,
- Megan Brashear,
- Gerome Breen,
- Richard A. Bryant,
- Angela C. Bustamante,
- Jonas Bybjerg-Grauholm,
- Joseph R. Calabrese,
- José M. Caldas- de- Almeida,
- Anders M. Dale,
- Mark J. Daly,
- Nikolaos P. Daskalakis,
- Jürgen Deckert,
- Douglas L. Delahanty,
- Michelle F. Dennis,
- Seth G. Disner,
- Katharina Domschke,
- Alma Dzubur-Kulenovic,
- Christopher R. Erbes,
- Alexandra Evans,
- Lindsay A. Farrer,
- Norah C. Feeny,
- Janine D. Flory,
- David Forbes,
- Carol E. Franz,
- Sandro Galea,
- Melanie E. Garrett,
- Bizu Gelaye,
- Elbert Geuze,
- Charles Gillespie,
- Aferdita Goci Uka,
- Scott D. Gordon,
- Guia Guffanti,
- Rasha Hammamieh,
- Supriya Harnal,
- Michael A. Hauser,
- Andrew C. Heath,
- Sian M. J. Hemmings,
- David Michael Hougaard,
- Miro Jakovljevic,
- Marti Jett,
- Eric Otto Johnson,
- Ian Jones,
- Tanja Jovanovic,
- Xue-Jun Qin,
- Angela G. Junglen,
- Karen-Inge Karstoft,
- Milissa L. Kaufman,
- Ronald C. Kessler,
- Alaptagin Khan,
- Nathan A. Kimbrel,
- Anthony P. King,
- Nastassja Koen,
- Henry R. Kranzler,
- William S. Kremen,
- Bruce R. Lawford,
- Lauren A. M. Lebois,
- Catrin E. Lewis,
- Sarah D. Linnstaedt,
- Adriana Lori,
- Bozo Lugonja,
- Jurjen J. Luykx,
- Michael J. Lyons,
- Jessica Maples-Keller,
- Charles Marmar,
- Alicia R. Martin,
- Nicholas G. Martin,
- Douglas Maurer,
- Matig R. Mavissakalian,
- Alexander McFarlane,
- Regina E. McGlinchey,
- Katie A. McLaughlin,
- Samuel A. McLean,
- Sarah McLeay,
- Divya Mehta,
- William P. Milberg,
- Mark W. Miller,
- Rajendra A. Morey,
- Charles Phillip Morris,
- Ole Mors,
- Preben B. Mortensen,
- Benjamin M. Neale,
- Elliot C. Nelson,
- Merete Nordentoft,
- Sonya B. Norman,
- Meaghan O’Donnell,
- Holly K. Orcutt,
- Matthew S. Panizzon,
- Edward S. Peters,
- Alan L. Peterson,
- Matthew Peverill,
- Robert H. Pietrzak,
- Melissa A. Polusny,
- John P. Rice,
- Stephan Ripke,
- Victoria B. Risbrough,
- Andrea L. Roberts,
- Alex O. Rothbaum,
- Barbara O. Rothbaum,
- Peter Roy-Byrne,
- Ken Ruggiero,
- Ariane Rung,
- Bart P. F. Rutten,
- Nancy L. Saccone,
- Sixto E. Sanchez,
- Dick Schijven,
- Soraya Seedat,
- Antonia V. Seligowski,
- Julia S. Seng,
- Christina M. Sheerin,
- Derrick Silove,
- Alicia K. Smith,
- Jordan W. Smoller,
- Scott R. Sponheim,
- Dan J. Stein,
- Jennifer S. Stevens,
- Jennifer A. Sumner,
- Martin H. Teicher,
- Wesley K. Thompson,
- Edward Trapido,
- Monica Uddin,
- Robert J. Ursano,
- Leigh Luella van den Heuvel,
- Miranda Van Hooff,
- Eric Vermetten,
- Christiaan H. Vinkers,
- Joanne Voisey,
- Yunpeng Wang,
- Zhewu Wang,
- Thomas Werge,
- Michelle A. Williams,
- Douglas E. Williamson,
- Sherry Winternitz,
- Christiane Wolf,
- Erika J. Wolf,
- Jonathan D. Wolff,
- Rachel Yehuda,
- Ross McD. Young,
- Keith A. Young,
- Hongyu Zhao,
- Lori A. Zoellner,
- Israel Liberzon,
- Kerry J. Ressler,
- Magali Haas,
- Karestan C. Koenen
Affiliations
- Caroline M. Nievergelt
- University of California San Diego, Department of Psychiatry
- Adam X. Maihofer
- University of California San Diego, Department of Psychiatry
- Torsten Klengel
- Harvard Medical School, Department of Psychiatry
- Elizabeth G. Atkinson
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Chia-Yen Chen
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Karmel W. Choi
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Jonathan R. I. Coleman
- King’s College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience
- Shareefa Dalvie
- University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town
- Laramie E. Duncan
- Stanford University, Department of Psychiatry and Behavioral Sciences
- Joel Gelernter
- US Department of Veterans Affairs, Department of Psychiatry
- Daniel F. Levey
- VA Connecticut Healthcare Center
- Mark W. Logue
- VA Boston Healthcare System, National Center for PTSD
- Renato Polimanti
- VA Connecticut Healthcare Center
- Allison C. Provost
- Cohen Veterans Bioscience
- Andrew Ratanatharathorn
- Harvard T.H. Chan School of Public Health, Department of Epidemiology
- Murray B. Stein
- University of California San Diego, Department of Psychiatry
- Katy Torres
- University of California San Diego, Department of Psychiatry
- Allison E. Aiello
- Gillings School of Global Public Health, Department of Epidemiology
- Lynn M. Almli
- Emory University, Department of Psychiatry and Behavioral Sciences
- Ananda B. Amstadter
- Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
- Søren B. Andersen
- The Danish Veteran Centre, Research and Knowledge Centre
- Ole A. Andreassen
- University of Oslo, Institute of Clinical Medicine
- Paul A. Arbisi
- Minneapolis VA Health Care System, Mental Health Service Line
- Allison E. Ashley-Koch
- Duke University, Duke Molecular Physiology Institute
- S. Bryn Austin
- Harvard Medical School, Department of Psychiatry
- Esmina Avdibegovic
- University Clinical Center of Tuzla, Department of Psychiatry
- Dragan Babić
- University Clinical Center of Mostar, Department of Psychiatry
- Marie Bækvad-Hansen
- Statens Serum Institut, Department for Congenital Disorders
- Dewleen G. Baker
- University of California San Diego, Department of Psychiatry
- Jean C. Beckham
- Durham VA Medical Center, Research
- Laura J. Bierut
- Washington University in Saint Louis School of Medicine, Department of Psychiatry
- Jonathan I. Bisson
- Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics
- Marco P. Boks
- UMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht
- Elizabeth A. Bolger
- Harvard Medical School, Department of Psychiatry
- Anders D. Børglum
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Bekh Bradley
- Emory University, Department of Psychiatry and Behavioral Sciences
- Megan Brashear
- Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology
- Gerome Breen
- King’s College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience
- Richard A. Bryant
- University of New South Wales, Department of Psychology
- Angela C. Bustamante
- University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine
- Jonas Bybjerg-Grauholm
- Statens Serum Institut, Department for Congenital Disorders
- Joseph R. Calabrese
- University Hospitals, Department of Psychiatry
- José M. Caldas- de- Almeida
- CEDOC -Chronic Diseases Research Centre, Lisbon Institute of Global Mental Health
- Anders M. Dale
- University of California San Diego, Department of Radiology, Department of Neurosciences
- Mark J. Daly
- Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU)
- Nikolaos P. Daskalakis
- Harvard Medical School, Department of Psychiatry
- Jürgen Deckert
- University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy
- Douglas L. Delahanty
- Kent State University, Department of Psychological Sciences
- Michelle F. Dennis
- Durham VA Medical Center, Research
- Seth G. Disner
- Minneapolis VA Health Care System, Research Service Line
- Katharina Domschke
- Medical Center-University of Freiburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy
- Alma Dzubur-Kulenovic
- University Clinical Center of Sarajevo, Department of Psychiatry
- Christopher R. Erbes
- University of Minnesota, Department of Psychiatry
- Alexandra Evans
- Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff
- Lindsay A. Farrer
- Boston University School of Medicine, Department of Medicine
- Norah C. Feeny
- Case Western Reserve University, Department of Psychological Sciences
- Janine D. Flory
- Icahn School of Medicine at Mount Sinai, Department of Psychiatry
- David Forbes
- University of Melbourne, Department of Psychiatry, Melbourne
- Carol E. Franz
- University of California San Diego, Department of Psychiatry
- Sandro Galea
- Boston University, Department of Psychological and Brain Sciences
- Melanie E. Garrett
- Duke University, Department of Psychiatry and Behavioral Sciences
- Bizu Gelaye
- Harvard T.H. Chan School of Public Health, Department of Epidemiology
- Elbert Geuze
- Netherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht
- Charles Gillespie
- Emory University, Department of Psychiatry and Behavioral Sciences
- Aferdita Goci Uka
- University Clinical Centre of Kosovo, Department of Psychiatry, Prishtina
- Scott D. Gordon
- QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology
- Guia Guffanti
- Harvard Medical School, Department of Psychiatry
- Rasha Hammamieh
- US Army Medical Research and Materiel Command, USACEHR
- Supriya Harnal
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Michael A. Hauser
- Duke University, Department of Psychiatry and Behavioral Sciences
- Andrew C. Heath
- Washington University in Saint Louis School of Medicine, Department of Genetics
- Sian M. J. Hemmings
- Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town
- David Michael Hougaard
- Statens Serum Institut, Department for Congenital Disorders
- Miro Jakovljevic
- University Hospital Center of Zagreb, Department of Psychiatry
- Marti Jett
- US Army Medical Research and Materiel Command, USACEHR
- Eric Otto Johnson
- RTI International, Behavioral Health and Criminal Justice Division
- Ian Jones
- Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff
- Tanja Jovanovic
- Emory University, Department of Psychiatry and Behavioral Sciences
- Xue-Jun Qin
- Duke University, Duke Molecular Physiology Institute
- Angela G. Junglen
- Kent State University, Department of Psychological Sciences
- Karen-Inge Karstoft
- The Danish Veteran Centre, Research and Knowledge Centre
- Milissa L. Kaufman
- Harvard Medical School, Department of Psychiatry
- Ronald C. Kessler
- Harvard Medical School, Department of Psychiatry
- Alaptagin Khan
- McLean Hospital
- Nathan A. Kimbrel
- Duke University, Duke Molecular Physiology Institute
- Anthony P. King
- University of Michigan Medical School, Department of Psychiatry
- Nastassja Koen
- University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town
- Henry R. Kranzler
- University of Pennsylvania Perelman School of Medicine, Department of Psychiatry
- William S. Kremen
- University of California San Diego, Department of Psychiatry
- Bruce R. Lawford
- Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove
- Lauren A. M. Lebois
- Harvard Medical School, Department of Psychiatry
- Catrin E. Lewis
- Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff
- Sarah D. Linnstaedt
- UNC Institute for Trauma Recovery, Department of Anesthesiology
- Adriana Lori
- Emory University, Department of Gynecology and Obstetrics
- Bozo Lugonja
- Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff
- Jurjen J. Luykx
- UMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht
- Michael J. Lyons
- Boston University, Dean’s Office
- Jessica Maples-Keller
- Emory University, Department of Psychiatry and Behavioral Sciences
- Charles Marmar
- New York University School of Medicine, Department of Psychiatry
- Alicia R. Martin
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology
- Douglas Maurer
- United States Army, Command
- Matig R. Mavissakalian
- University Hospitals, Department of Psychiatry
- Alexander McFarlane
- University of Adelaide, Department of Psychiatry, Adelaide
- Regina E. McGlinchey
- VA Boston Health Care System, GRECC/TRACTS
- Katie A. McLaughlin
- Harvard University, Department of Psychology
- Samuel A. McLean
- UNC Institute for Trauma Recovery, Department of Anesthesiology
- Sarah McLeay
- Gallipoli Medical Research Institute, PTSD Initiative, Greenslopes
- Divya Mehta
- Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove
- William P. Milberg
- VA Boston Health Care System, GRECC/TRACTS
- Mark W. Miller
- VA Boston Healthcare System, National Center for PTSD
- Rajendra A. Morey
- Duke University, Duke Molecular Physiology Institute
- Charles Phillip Morris
- Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove
- Ole Mors
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Preben B. Mortensen
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Benjamin M. Neale
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Elliot C. Nelson
- Washington University in Saint Louis School of Medicine, Department of Psychiatry
- Merete Nordentoft
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Sonya B. Norman
- University of California San Diego, Department of Psychiatry
- Meaghan O’Donnell
- University of Melbourne, Department of Psychiatry, Melbourne
- Holly K. Orcutt
- Northern Illinois University, Department of Psychology
- Matthew S. Panizzon
- University of California San Diego, Department of Psychiatry
- Edward S. Peters
- Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology
- Alan L. Peterson
- University of Texas Health Science Center at San Antonio, Department of Psychiatry
- Matthew Peverill
- University of Washington, Department of Psychology
- Robert H. Pietrzak
- Yale University School of Medicine, Department of Psychiatry
- Melissa A. Polusny
- University of Minnesota, Department of Psychiatry
- John P. Rice
- Washington University in Saint Louis School of Medicine, Department of Psychiatry
- Stephan Ripke
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Victoria B. Risbrough
- University of California San Diego, Department of Psychiatry
- Andrea L. Roberts
- Harvard T.H. Chan School of Public Health, Department of Environmental Health
- Alex O. Rothbaum
- Case Western Reserve University, Department of Psychological Sciences
- Barbara O. Rothbaum
- Emory University, Department of Psychiatry and Behavioral Sciences
- Peter Roy-Byrne
- University of Washington, Department of Psychology
- Ken Ruggiero
- Medical University of South Carolina, Department of Nursing and Department of Psychiatry
- Ariane Rung
- Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology
- Bart P. F. Rutten
- Maastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht
- Nancy L. Saccone
- Washington University in Saint Louis School of Medicine, Department of Psychiatry
- Sixto E. Sanchez
- Universidad Peruana de Ciencias Aplicadas Facultad de Ciencias de la Salud, Department of Medicine, Lima
- Dick Schijven
- UMC Utrecht Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht
- Soraya Seedat
- Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town
- Antonia V. Seligowski
- Harvard Medical School, Department of Psychiatry
- Julia S. Seng
- University of Michigan, School of Nursing
- Christina M. Sheerin
- Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry
- Derrick Silove
- University of New South Wales, Department of Psychiatry, Sydney
- Alicia K. Smith
- Emory University, Department of Psychiatry and Behavioral Sciences
- Jordan W. Smoller
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- Scott R. Sponheim
- Minneapolis VA Health Care System, Mental Health Service Line
- Dan J. Stein
- University of Cape Town, SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Cape Town
- Jennifer S. Stevens
- Emory University, Department of Psychiatry and Behavioral Sciences
- Jennifer A. Sumner
- Columbia University Medical Center, Department of Medicine
- Martin H. Teicher
- Harvard Medical School, Department of Psychiatry
- Wesley K. Thompson
- University of California San Diego, Department of Psychiatry
- Edward Trapido
- Louisiana State University Health Sciences Center, School of Public Health and Department of Epidemiology
- Monica Uddin
- University of South Florida College of Public Health, Genomics Program
- Robert J. Ursano
- Uniformed Services University, Department of Psychiatry
- Leigh Luella van den Heuvel
- Stellenbosch University Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town
- Miranda Van Hooff
- University of Adelaide, Department of Psychiatry, Adelaide
- Eric Vermetten
- New York University School of Medicine, Department of Psychiatry
- Christiaan H. Vinkers
- Amsterdam UMC (location VUmc), Department of Anatomy and Neurosciences, Amsterdam
- Joanne Voisey
- Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove
- Yunpeng Wang
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Zhewu Wang
- Ralph H Johnson VA Medical Center, Department of Mental Health
- Thomas Werge
- The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Michelle A. Williams
- Harvard T.H. Chan School of Public Health, Department of Epidemiology
- Douglas E. Williamson
- Durham VA Medical Center, Research
- Sherry Winternitz
- Harvard Medical School, Department of Psychiatry
- Christiane Wolf
- University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy
- Erika J. Wolf
- VA Boston Healthcare System, National Center for PTSD
- Jonathan D. Wolff
- McLean Hospital
- Rachel Yehuda
- Icahn School of Medicine at Mount Sinai, Department of Psychiatry
- Ross McD. Young
- Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove
- Keith A. Young
- Baylor Scott and White Central Texas, Department of Psychiatry
- Hongyu Zhao
- Yale University, Department of Biostatistics
- Lori A. Zoellner
- University of Washington, Department of Psychiatry and Behavioral Sciences
- Israel Liberzon
- University of Michigan Medical School, Department of Psychiatry
- Kerry J. Ressler
- Harvard Medical School, Department of Psychiatry
- Magali Haas
- Cohen Veterans Bioscience
- Karestan C. Koenen
- Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research
- DOI
- https://doi.org/10.1038/s41467-019-12576-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.
