NT-proBNP point-of-care testing for predicting mortality in end-stage renal disease: A survival analysis
Chun Chen,
Yin-Chen Hsu,
Kuang-Wei Chou,
Kuo-Song Chang,
Ya-Hui Hsu,
Wei-Huai Chiu,
Chun-Wei Lee,
Po-Sheng Yang,
Wen-Han Chang,
Yao-Kuang Huang,
Pang-Yen Chen,
Chien-Wei Chen,
Yu-Jang Su
Affiliations
Chun Chen
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan
Yin-Chen Hsu
Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan
Kuang-Wei Chou
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan
Kuo-Song Chang
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine Nursing and Management, Taipei, Taiwan
Ya-Hui Hsu
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan
Wei-Huai Chiu
Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei, Taiwan
Chun-Wei Lee
Mackay Junior College of Medicine Nursing and Management, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, Taiwan; Cardiovascular Division, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan
Po-Sheng Yang
Department of Medicine, MacKay Medical College, New Taipei, Taiwan; Department of general surgery, MacKay Memorial Hospital, Taipei, Taiwan
Wen-Han Chang
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan; Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei, Taiwan; School of Medicine, Taipei Medical University, Taipei, Taiwan
Yao-Kuang Huang
Chang Gung University, College of Medicine, Taoyuan, Taiwan; Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan; Division of Thoracic and Cardiovascular Surgery, Chia Yi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan
Pang-Yen Chen
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Mackay Junior College of Medicine Nursing and Management, Taipei, Taiwan
Chien-Wei Chen
Department of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Corresponding author. Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Yu-Jang Su
Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan; Mackay Junior College of Medicine Nursing and Management, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei, Taiwan; Division of Toxicology, Mackay Memorial Hospital, Taipei, 10449, Taiwan; Corresponding author. Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan
This study examines the predictive value of elevated N-terminal-pro brain natriuretic peptide (NT-pro BNP) levels for mortality among patients with end-stage renal disease (ESRD). Data from 768 ESRD patients, excluding those with cancer or lost follow-up, were analyzed using Kaplan–Meier curves and Cox proportional hazards models over three years. Results indicated that patients with very high NT-pro BNP levels had shorter average survival times and a significantly higher risk of mortality (hazard ratio 1.43). Advanced age, ICU admission, and comorbidities like cerebrovascular diseases and chronic obstructive pulmonary disease also contributed to increased mortality risks. Thus, elevated NT-pro BNP is an independent risk factor for mortality in ESRD patients.
