Indian Journal of Ophthalmology (Jan 2019)

Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies

  • Subramaniam Rajesh Bharathi Devi,
  • Karunakaran Coral,
  • Karthikeyan Gayathree,
  • Muthuvel Bharathselvi,
  • Shanmuganathan Sivasankar,
  • Jyotirmoy Biswas,
  • Pukhraj Rishi,
  • Sundaram Natarajan,
  • Sengamedu Srinivasa Badrinath,
  • Narayanasamy Angayarkanni

DOI
https://doi.org/10.4103/ijo.IJO_400_19
Journal volume & issue
Vol. 67, no. 10
pp. 1762 – 1765

Abstract

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We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.

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