Nature Communications (Oct 2020)
SARS-CoV-2 viral load is associated with increased disease severity and mortality
- Jesse Fajnzylber,
- James Regan,
- Kendyll Coxen,
- Heather Corry,
- Colline Wong,
- Alexandra Rosenthal,
- Daniel Worrall,
- Francoise Giguel,
- Alicja Piechocka-Trocha,
- Caroline Atyeo,
- Stephanie Fischinger,
- Andrew Chan,
- Keith T. Flaherty,
- Kathryn Hall,
- Michael Dougan,
- Edward T. Ryan,
- Elizabeth Gillespie,
- Rida Chishti,
- Yijia Li,
- Nikolaus Jilg,
- Dusan Hanidziar,
- Rebecca M. Baron,
- Lindsey Baden,
- Athe M. Tsibris,
- Katrina A. Armstrong,
- Daniel R. Kuritzkes,
- Galit Alter,
- Bruce D. Walker,
- Xu Yu,
- Jonathan Z. Li,
- The Massachusetts Consortium for Pathogen Readiness
Affiliations
- Jesse Fajnzylber
- Brigham and Women’s Hospital, Harvard Medical School
- James Regan
- Brigham and Women’s Hospital, Harvard Medical School
- Kendyll Coxen
- Brigham and Women’s Hospital, Harvard Medical School
- Heather Corry
- Brigham and Women’s Hospital, Harvard Medical School
- Colline Wong
- Brigham and Women’s Hospital, Harvard Medical School
- Alexandra Rosenthal
- Brigham and Women’s Hospital, Harvard Medical School
- Daniel Worrall
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Francoise Giguel
- Massachusetts General Hospital, Harvard Medical School
- Alicja Piechocka-Trocha
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Caroline Atyeo
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Stephanie Fischinger
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Andrew Chan
- Massachusetts General Hospital, Harvard Medical School
- Keith T. Flaherty
- Massachusetts General Hospital, Harvard Medical School
- Kathryn Hall
- Massachusetts General Hospital, Harvard Medical School
- Michael Dougan
- Massachusetts General Hospital, Harvard Medical School
- Edward T. Ryan
- Massachusetts General Hospital, Harvard Medical School
- Elizabeth Gillespie
- Brigham and Women’s Hospital, Harvard Medical School
- Rida Chishti
- Brigham and Women’s Hospital, Harvard Medical School
- Yijia Li
- Brigham and Women’s Hospital, Harvard Medical School
- Nikolaus Jilg
- Brigham and Women’s Hospital, Harvard Medical School
- Dusan Hanidziar
- Massachusetts General Hospital, Harvard Medical School
- Rebecca M. Baron
- Brigham and Women’s Hospital, Harvard Medical School
- Lindsey Baden
- Brigham and Women’s Hospital, Harvard Medical School
- Athe M. Tsibris
- Brigham and Women’s Hospital, Harvard Medical School
- Katrina A. Armstrong
- Massachusetts General Hospital, Harvard Medical School
- Daniel R. Kuritzkes
- Brigham and Women’s Hospital, Harvard Medical School
- Galit Alter
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Bruce D. Walker
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Xu Yu
- Ragon Institute of MGH, MIT and Harvard, Harvard Medical School
- Jonathan Z. Li
- Brigham and Women’s Hospital, Harvard Medical School
- The Massachusetts Consortium for Pathogen Readiness
- DOI
- https://doi.org/10.1038/s41467-020-19057-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.
