Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Debashis Sahoo; Lee Swanson; Ibrahim M. Sayed; Gajanan D. Katkar; Stella-Rita Ibeawuchi; Yash Mittal; Rama F. Pranadinata; Courtney Tindle; Mackenzie Fuller; Dominik L. Stec; John T. Chang; William J. Sandborn; Soumita Das; Pradipta Ghosh

doi:10.1038/s41467-021-24470-5

Nature Communications (Jul 2021)

Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease

Debashis Sahoo,
Lee Swanson,
Ibrahim M. Sayed,
Gajanan D. Katkar,
Stella-Rita Ibeawuchi,
Yash Mittal,
Rama F. Pranadinata,
Courtney Tindle,
Mackenzie Fuller,
Dominik L. Stec,
John T. Chang,
William J. Sandborn,
Soumita Das,
Pradipta Ghosh

Affiliations

Debashis Sahoo: Department of Pediatrics, University of California San Diego
Lee Swanson: Department of Cellular and Molecular Medicine, University of California San Diego
Ibrahim M. Sayed: Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University
Gajanan D. Katkar: Department of Cellular and Molecular Medicine, University of California San Diego
Stella-Rita Ibeawuchi: Department of Pathology, University of California San Diego
Yash Mittal: Department of Medicine, University of California San Diego
Rama F. Pranadinata: Department of Cellular and Molecular Medicine, University of California San Diego
Courtney Tindle: Department of Cellular and Molecular Medicine, University of California San Diego
Mackenzie Fuller: Department of Cellular and Molecular Medicine, University of California San Diego
Dominik L. Stec: Department of Cellular and Molecular Medicine, University of California San Diego
John T. Chang: Department of Medicine, University of California San Diego
William J. Sandborn: Department of Medicine, University of California San Diego
Soumita Das: Department of Pathology, University of California San Diego
Pradipta Ghosh: Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego

DOI: https://doi.org/10.1038/s41467-021-24470-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and protect the leaky gut barrier in inflammatory bowel disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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