Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.

Abstract

Little is known about the interactions of apolipoprotein (Apo) A5 gene polymorphisms and alcohol consumption on serum lipid profiles. The present study was undertaken to detect the interactions of ApoA5-1131T>C, c.553G>T and c.457G>A polymorphisms and alcohol consumption on serum lipid levels.A total of 516 nondrinkers and 514 drinkers were randomly selected from our previous stratified randomized cluster samples. Genotyping was performed by polymerase chain reaction and restriction fragment length polymorphism. The levels of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), ApoA1 and ApoB were higher in drinkers than in nondrinkers (PC genotypes and alcohol consumption on ApoB levels (PT genotypes and alcohol consumption on low-density lipoprotein cholesterol (LDL-C) levels (PA genotypes and alcohol consumption on TG levels (PC genotypes were correlated with TG, and c.553G>T and c.457G>A genotypes were associated with HDL-C levels in nondrinkers (PC genotypes were correlated with TC, TG, LDL-C, ApoB levels and the ApoA1/ApoB ratio (PT genotypes were correlated with TC, TG, HDL-C and LDL-C levels (PA genotypes were associated with TG, LDL-C, ApoA1 and ApoB levels (P<0.05-0.01).The differences in some serum lipid parameters between the drinkers and nondrinkers might partly result from different interactions of the ApoA5 gene polymorphisms and alcohol consumption.