Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs

Arvind Kumar; Kayla Kindig; Shanlin Rao; Afroditi-Maria Zaki; Sandip Basak; Mark S. P. Sansom; Philip C. Biggin; Sudha Chakrapani

doi:10.1038/s41467-022-32594-5

Nature Communications (Aug 2022)

Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs

Arvind Kumar,
Kayla Kindig,
Shanlin Rao,
Afroditi-Maria Zaki,
Sandip Basak,
Mark S. P. Sansom,
Philip C. Biggin,
Sudha Chakrapani

Affiliations

Arvind Kumar: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University
Kayla Kindig: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University
Shanlin Rao: Department of Biochemistry, University of Oxford
Afroditi-Maria Zaki: Department of Biochemistry, University of Oxford
Sandip Basak: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University
Mark S. P. Sansom: Department of Biochemistry, University of Oxford
Philip C. Biggin: Department of Biochemistry, University of Oxford
Sudha Chakrapani: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-022-32594-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Glycine receptors (GlyRs) mediate motor control and pain perception. Here, Kumar et al. present structures of GlyR bound to Δ9 -tetrahydrocannabinol (THC) using cryo-electron microscopy, providing insight into the therapeutic effects of cannabinoids.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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