Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Elizabeth S. Thrall; James E. Kath; Seungwoo Chang; Joseph J. Loparo

doi:10.1038/s41467-017-02333-2

Nature Communications (Dec 2017)

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Elizabeth S. Thrall,
James E. Kath,
Seungwoo Chang,
Joseph J. Loparo

Affiliations

Elizabeth S. Thrall: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
James E. Kath: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Seungwoo Chang: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Joseph J. Loparo: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-02333-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Translesion synthesis (TLS) enables cells to tolerate damaged DNA encountered during replication. Here the authors use super-resolution photoactivation localization microscopy to reveal a lesion type dependent mechanism of recruitment of the TLS polymerase Pol IV following DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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