Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

Shenglin Cai; Thomas Pataillot-Meakin; Akifumi Shibakawa; Ren Ren; Charlotte L. Bevan; Sylvain Ladame; Aleksandar P. Ivanov; Joshua B. Edel

doi:10.1038/s41467-021-23497-y

Nature Communications (Jun 2021)

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

Shenglin Cai,
Thomas Pataillot-Meakin,
Akifumi Shibakawa,
Ren Ren,
Charlotte L. Bevan,
Sylvain Ladame,
Aleksandar P. Ivanov,
Joshua B. Edel

Affiliations

Shenglin Cai: Department of Chemistry, Imperial College London, Molecular Science Research Hub
Thomas Pataillot-Meakin: Department of Chemistry, Imperial College London, Molecular Science Research Hub
Akifumi Shibakawa: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital
Ren Ren: Department of Chemistry, Imperial College London, Molecular Science Research Hub
Charlotte L. Bevan: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital
Sylvain Ladame: Department of Bioengineering, Imperial College London, Sir Michael Uren Hub
Aleksandar P. Ivanov: Department of Chemistry, Imperial College London, Molecular Science Research Hub
Joshua B. Edel: Department of Chemistry, Imperial College London, Molecular Science Research Hub

DOI: https://doi.org/10.1038/s41467-021-23497-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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miRNA profiling from patient blood can be used for cancer diagnosis. Here the authors present an electro-optical nanopore sensing platform which allows sensitive and specific miRNA detection directly in human serum and apply to monitoring of miR-141-3p and miR-375-3p in different stage of prostate cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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