Nature Communications (Jul 2020)
Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
- John E. Blume,
- William C. Manning,
- Gregory Troiano,
- Daniel Hornburg,
- Michael Figa,
- Lyndal Hesterberg,
- Theodore L. Platt,
- Xiaoyan Zhao,
- Rea A. Cuaresma,
- Patrick A. Everley,
- Marwin Ko,
- Hope Liou,
- Max Mahoney,
- Shadi Ferdosi,
- Eltaher M. Elgierari,
- Craig Stolarczyk,
- Behzad Tangeysh,
- Hongwei Xia,
- Ryan Benz,
- Asim Siddiqui,
- Steven A. Carr,
- Philip Ma,
- Robert Langer,
- Vivek Farias,
- Omid C. Farokhzad
Affiliations
- John E. Blume
- Seer, Inc.
- William C. Manning
- Seer, Inc.
- Gregory Troiano
- Seer, Inc.
- Daniel Hornburg
- Seer, Inc.
- Michael Figa
- Seer, Inc.
- Lyndal Hesterberg
- Seer, Inc.
- Theodore L. Platt
- Seer, Inc.
- Xiaoyan Zhao
- Seer, Inc.
- Rea A. Cuaresma
- Seer, Inc.
- Patrick A. Everley
- Seer, Inc.
- Marwin Ko
- Seer, Inc.
- Hope Liou
- Seer, Inc.
- Max Mahoney
- Seer, Inc.
- Shadi Ferdosi
- Seer, Inc.
- Eltaher M. Elgierari
- Seer, Inc.
- Craig Stolarczyk
- Seer, Inc.
- Behzad Tangeysh
- Seer, Inc.
- Hongwei Xia
- Seer, Inc.
- Ryan Benz
- Seer, Inc.
- Asim Siddiqui
- Seer, Inc.
- Steven A. Carr
- Broad Institute of MIT and Harvard
- Philip Ma
- Seer, Inc.
- Robert Langer
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Vivek Farias
- Sloan School and Operations Research Center, Massachusetts Institute of Technology
- Omid C. Farokhzad
- Seer, Inc.
- DOI
- https://doi.org/10.1038/s41467-020-17033-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.
