Anti-oxidant effect of N-acetyl cysteine in dogs with chronic kidney disease

Abstract

The present study was carried out with the objectives of assessing oxidative stress in dogs with chronic kidney disease (CKD) and evaluating response to treatment with N-acetyl cysteine (NAC). Dogs diagnosed with stage III CKD as per the guidelines of the International Renal Interest Society (IRIS) were included in the study. The animals were divided into two groups. Animals of one group were given standard therapy for CKD and the animals of the second group were administered NAC along with standard therapy. Oxidative stress parameters such as total antioxidant status (TAS), serum malondialdehyde (MDA) level and plasma glutathione peroxidase (GSH-Px) activity were studied. On the day of presentation, a significant increase in the mean values of serum MDA and TAS were observed in diseased animals compared to healthy animals, whereas a significant decline was noted in plasma GSH-Px activity. After treatment, a significant decline in serum MDA and TAS were recorded in animals of group II receiving NAC therapy. A significant increase in plasma glutathione GSH-Px activity was recorded in this group. N-acetyl cysteine therapy was found to be effective in the management of oxidative stress in dogs with chronic kidney disease.

Keywords

• chronic kidney disease
• n-acetyl cysteine
• oxidative stress