Frontiers in Pharmacology (Jun 2024)

Efficacy and safety of Osteoking on fracture healing: a systematic review and meta-analysis

  • Le Zhang,
  • Haomin Kuang,
  • Zimin Zhang,
  • Kuan Rong,
  • Yiwei Yuan,
  • Zhifei Peng,
  • Haomin Zhao,
  • Ke Liu,
  • Liang Ou,
  • Jianjun Kuang,
  • Jianjun Kuang

DOI
https://doi.org/10.3389/fphar.2024.1363421
Journal volume & issue
Vol. 15

Abstract

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BackgroundOsteoking (OK) is prescribed in traditional Chinese medicine to accelerate fracture healing. Although some studies suggest the potential efficacy of OK for fracture healing, the evidence remains inconclusive.AimTo systematically evaluate the safety of OK and its effect on fracture healing.MethodsRelevant authoritative databases were searched until 25 August 2023. Randomized controlled trials (RCTs) of patients with fractures treated with Osteoking were included. We evaluated the risk of bias using the Cochrane tool and performed a meta-analysis using the Review Manager 5.4 software package.Results13 studies involving 1123 participants were included. This meta-analysis showed that compared with observations in the control group, the OK group showed a shortened fracture healing time, increased fracture healing rate, reduced swelling regression time and ecchymosis regression time, and improved bone metabolism. In addition, the included studies did not report any serious side effects associated with the use of OK, and the mild side effects resolved without treatment.ConclusionOK therapy is beneficial and safe for accelerating fracture healing, reducing swelling, eliminating ecchymosis, and improving bone metabolism. However, the meta-analysis results do not support OK treatment for improving the fracture healing rate at all fracture sites and reducing pain across all fracture sites. Further original, high-quality studies are needed to validate these findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=452430, identifier CRD42023452430.

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