mSphere (Aug 2021)

Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides

  • Melanie D. Balhuizen,
  • Albert van Dijk,
  • Jeroen W. A. Jansen,
  • Chris H. A. van de Lest,
  • Edwin J. A. Veldhuizen,
  • Henk P. Haagsman

DOI
https://doi.org/10.1128/mSphere.00523-21
Journal volume & issue
Vol. 6, no. 4

Abstract

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Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high potential as alternatives to antibiotics due to low resistance development.