Revista da Sociedade Portuguesa de Dermatologia e Venereologia (Dec 2018)

Fatal Orbital Pyoderma Gangrenosum with Central Nervous System Involvement

  • Sofia Lopes,
  • Júlia Vide,
  • Sofia Magina,
  • Ana Paula Cunha,
  • Filomena Azevedo

DOI
https://doi.org/10.29021/spdv.76.4.952
Journal volume & issue
Vol. 76, no. 4

Abstract

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Pyoderma gangrenosum is a chronic inflammatory disease characterized by the development of a painful deep ulcer with undermined borders. Head and neck are rarely affected regions of the body and also usually associated with a worse prognosis. Corticosteroids are the mainstay of treatment although available options are not specific nor completely effective in pyoderma gangrenosum. We report the case of a 46-year-old patient with an aggressive orbital pyoderma gangrenosum with progressive extension to the central nervous system and insufficient response to treatment, ultimately leading to patient’s death.

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